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Article

Association between a genetic variant of type-1 cannabinoid receptor and inflammatory neurodegeneration in multiple sclerosis.

PloS one - 1 Jan 2013

Rossi Silvia, Bozzali Marco, Bari Monica, Mori Francesco, Studer Valeria, Motta Caterina, Buttari Fabio, Cercignani Mara, Gravina Paolo, Mastrangelo Nicolina, Castelli Maura, Mancino Raffaele, Nucci Carlo, Sottile Fabrizio, Bernardini Sergio, Maccarrone Mauro, Centonze Diego

Abstract excerpt

Genetic ablation of type-1 cannabinoid receptors (CB1Rs) exacerbates the neurodegenerative damage of experimental autoimmune encephalomyelitis, the rodent model of multiple sclerosis (MS). To address the role on CB1Rs in the pathophysiology of human MS, we first investigated the impact of AAT trinucleotide short tandem repeat polymorphism of CNR1 gene on CB1R cell expression, and secondly on the inflammatory...

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Source

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Identifiers

PMID: 24391723
DOI: 10.1371/journal.pone.0082848
PMCID: PMC3877004

Genes

CNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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