Article

Astrocyte CB <sub>1</sub> receptors drive blood-brain barrier disruption in CNS inflammatory disease

2025-06-24

Abstract excerpt

Reactive astrocytes shape central nervous system (CNS) inflammation and participate in myelin damage and repair mechanisms in multiple sclerosis (MS). Through the activation of cannabinoid CB 1 receptors (CB 1 R) expressed by neurons and oligodendrocyte lineage cells, endocannabinoid signaling restricts neurodegeneration and promote remyelination in preclinical MS models. However, despite accumulating evidence t...

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Identifiers and source

Literature Corpus work: 877ab796-996e-5f35-82f4-4677a52f0702
DOI: 10.1101/2025.06.23.660998

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