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Article

Clinical events and their relation to the tumor necrosis factor-alpha and interleukin-10 genotypes in Sickle-Cell-Anemia patients.

Hematology/oncology and stem cell therapy - 1 Mar 2016

Cavalcante Jânio Emanuel Andrade, Machado Rosângela Pinheiro Gonçalves, Laurentino Marilia Rocha, dos Santos Talyta Ellen de Jesus, Bandeira Izabel Cristina Justino, Maia Filho Pedro Aurio, Figueiredo Monalisa Feliciano, Martins Alice Maria Costa, Lemes Romélia Pinheiro Gonçalves

Abstract excerpt

OBJECTIVE/BACKGROUND: Sickle-cell anemia (SCA) is a genetic blood disease characterized by chronic inflammation and a heterogeneous clinical picture. Serum tumor necrosis factor (TNF-alpha) and interleukin 10 (IL-10) levels are associated with the clinical course of SCA. This study aimed to evaluate the association between the frequency of the polymorphisms TNF-alpha-308 G→A, IL-10-1082 G→A, IL-10-819 C→T, and...

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Source

Identifiers

PMID: 26686970
DOI: 10.1016/j.hemonc.2015.11.002

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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