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Article

Patterning and growth control by membrane-tethered Wingless.

Nature - 9 Jan 2014

Alexandre Cyrille, Baena-Lopez Alberto, Vincent Jean-Paul

Abstract excerpt

Wnts are evolutionarily conserved secreted signalling proteins that, in various developmental contexts, spread from their site of synthesis to form a gradient and activate target-gene expression at a distance. However, the requirement for Wnts to spread has never been directly tested. Here we used genome engineering to replace the endogenous wingless gene, which encodes the main Drosophila Wnt, with one that...

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Identifiers

PMID: 24390349
DOI: 10.1038/nature12879
PMCID: PMC7611559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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