Article
Extracellular spreading of Wingless is required for Drosophila oogenesis.
PLoS genetics - 1 Apr 2021
Wang Xiaoxi, LaFever Kimberly S, Waghmare Indrayani, Page-McCaw Andrea
Abstract excerpt
Recent studies have investigated whether the Wnt family of extracellular ligands can signal at long range, spreading from their source and acting as morphogens, or whether they signal only in a juxtacrine manner to neighboring cells. The original evidence for long-range Wnt signaling arose from studies of Wg, a Drosophila Wnt protein, which patterns the wing disc over several cell diameters from a central source...
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