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Article

A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP.

Structure (London, England : 1993) - 4 Feb 2014

Hizukuri Yohei, Oda Takashi, Tabata Sanae, Tamura-Kawakami Keiko, Oi Rika, Sato Mamoru, Takagi Junichi, Akiyama Yoshinori, Nogi Terukazu

Abstract excerpt

During the extracytoplasmic stress response in Escherichia coli, the intramembrane protease RseP cleaves the anti-σ(E) protein RseA only after the membrane-anchored protease DegS truncates the periplasmic part of RseA that suppresses the action of RseP. Here we analyzed the three-dimensional structure of the two tandemly arranged PSD-95/Dlg/ZO-1 (PDZ) domains (PDZ tandem) present in the periplasmic region of RseP...

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PMID: 24389025
DOI: 10.1016/j.str.2013.12.003

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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