Article

A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ Binding Motif to the cytoplasm

2023-08-29

Abstract excerpt

The carboxy terminal tail of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein (E) contains a PDZ-binding motif (PBM) which is crucial for coronavirus pathogenicity. During SARS-CoV-2 infection, the viral E protein is expressed within the Golgi apparatus membrane of host cells with its PBM facing the cytoplasm. In this work we study the molecular mechanisms controlling the presentat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e0dd226-4f8d-5f7f-8bc7-6700c04c6e40
DOI: 10.1101/2023.08.29.555304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A short sequence in the tail of SARS-CoV-2 envelope protein controls accessibility of its PDZ Binding Motif to the cytoplasmDOI 10.1101/2023.08.29.555304Read

Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing ProteinsSemantic proximity Read

Interactions of SARS-CoV-2 protein E with cell junctions and polarity PDZ-containing proteinsSemantic proximity Read

Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein.Semantic proximity Read

The SARS-CoV-2 envelope PDZ Binding Motif acts as a virulence factor disrupting host’s epithelial cell-cell junctionsSemantic proximity Read

Coronavirus M proteins disperse the trans-Golgi network and inhibit anterograde protein trafficking in the secretory pathwaySemantic proximity Read

The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusionSemantic proximity Read

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins.Semantic proximity Read

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral PathogenesisSemantic proximity Read

The Tale of the Long Tail: the Cytoplasmic Domain of HIV-1 gp41Semantic proximity Read

A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP.Semantic proximity Read

N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle.Semantic proximity Read

Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins.Semantic proximity Read