Article
PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σ(E) activation in vivo.
Molecular microbiology - 1 Dec 2012
Hizukuri Yohei, Akiyama Yoshinori
Abstract excerpt
The Escherichia coli σ(E) extracytoplasmic stress response monitors and responds to folding stress in the cell envelope. A protease cascade directed at RseA, a membrane-spanning anti-σ that inhibits σ(E) activity, controls this critical signal-transduction system. Stress cues activate DegS to cleave RseA; a second cleavage by RseP releases RseA from the membrane, enabling its rapid degradation. Stress control...
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