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Article

Effect of changes in the flexible arm on tRNase Z processing kinetics.

The Journal of biological chemistry - 5 Jun 2009

Levinger Louis, Hopkinson Angela, Desetty Rohini, Wilson Christopher

Abstract excerpt

tRNAs are transcribed as precursors and processed in a series of reactions culminating in aminoacylation and translation. Central to tRNA maturation, the 3' end trailer can be endonucleolytically removed by tRNase Z. A flexible arm (FA) extruded from the body of tRNase Z consists of a structured alphaalphabetabeta hand that binds the elbow of pre-tRNA. Deleting the FA hand causes an almost 100-fold increase in Km...

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Identifiers

PMID: 19351879
DOI: 10.1074/jbc.M900745200
PMCID: PMC2708865

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