Article
The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation.
Nucleic acids research - 1 May 2013
Tan Min, Wang Meng, Zhou Xiao-Long, Yan Wei, Eriani Gilbert, Wang En-Duo
Abstract excerpt
Faithful translation of the genetic code depends on accurate coupling of amino acids with cognate transfer RNAs (tRNAs) catalyzed by aminoacyl-tRNA synthetases. The fidelity of leucyl-tRNA synthetase (LeuRS) depends mainly on proofreading at the pre- and post-transfer levels. During the catalytic cycle, the tRNA CCA-tail shuttles between the synthetic and editing domains to accomplish the aminoacylation and...
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