Article
Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions.
Nature communications - 22 May 2024
Duarte Rodrigo R R, Pain Oliver, Bendall Matthew L, de Mulder Rougvie Miguel, Marston Jez L, Selvackadunco Sashika, Troakes Claire, Leung Szi Kay, Bamford Rosemary A, Mill Jonathan, O'Reilly Paul F, Srivastava Deepak P, Nixon Douglas F, Powell Timothy R
Abstract excerpt
Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform specialised transcriptome-wide association studies that consider HERV expression quantified to precise genomic locations, using RNA sequencing and genetic data from 792 post-mortem brain samples. In Europeans, we identify 1238 HERVs with...
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