Article
SHORT COMMUNICATION: Apolipoprotein E genotype and cognition in bipolar disorder.
CNS neuroscience & therapeutics - 1 Oct 2010
Soeira-de-Souza Márcio Gerhardt, Soeiro de Souza Márcio Gerhardt, Bio Danielle Soares, Dias Vasco Videira, Martins do Prado Carolina, Campos Rodolfo Nunes, Costa Luis Felipe de Oliveira, Moreno Doris Hupfeld, Ojopi Elida Benquique, Gattaz Wagner Farid, Moreno Ricardo Alberto
Abstract excerpt
Apolipoprotein E (APOE) has been extensively studied as a risk factor for sporadic and late onset Alzheimer's Disease (AD). APOE allele (∗)3, the most frequent variant, is not associated to cognitive dysfunction (CD) or to increased AD risk. Differently, the (∗)4 allele is a well-established risk factor for CD, while the (∗)2 allele is associated with survival and longevity. CD is an important feature of Bipolar...
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