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Article

TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.

PLoS genetics - 1 Jan 2013

Ferguson Annabel A, Roy Sudipa, Kormanik Kaitlyn N, Kim Yongsoon, Dumas Kathleen J, Ritov Vladimir B, Matern Dietrich, Hu Patrick J, Fisher Alfred L

Abstract excerpt

Recent work has identified changes in the metabolism of the aromatic amino acid tyrosine as a risk factor for diabetes and a contributor to the development of liver cancer. While these findings could suggest a role for tyrosine as a direct regulator of the behavior of cells and tissues, evidence for this model is currently lacking. Through the use of RNAi and genetic mutants, we identify tatn-1, which is the worm...

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Identifiers

PMID: 24385923
DOI: 10.1371/journal.pgen.1004020
PMCID: PMC3868569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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