Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico approach to identify non-synonymous SNPs in human obesity related gene, MC3R (melanocortin-3-receptor).

Computational biology and chemistry - 1 Apr 2017

Singh Rajan Kumar, Mahalingam Kulandaivelu

Abstract excerpt

The melanocortin-3-receptor (MC3R) is a novel gene candidate for human obesity, which involved in controlling the energy homeostasis and food intake behavior. The main aim behind this work is to investigate the potentially deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in obesity related gene MC3R by using six computational tools viz., PolyPhen, I-Mutant, PROVEAN, SIFT, PANTHER and PhD-SNP....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Computer Simulation
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Chemical

Share to Models, Molecular

Share to Polymorphism, Single Nucleotide

Share to Receptor, Melanocortin, Type 3

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 28073065
DOI: 10.1016/j.compbiolchem.2016.12.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico approach to identify non-synonymous SNPs in human obesity related gene, MC3R (melanocortin-3-receptor).PMID 28073065Read ↗

Predictive Analysis of the Leptin-Melanocortin and Adiponectin Signaling Pathways in Obesity through In Silico TechniquesSemantic proximity Read ↗

Mutations in Melanocortin-3 Receptor Gene and Human Obesity.Semantic proximity Read ↗

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.Semantic proximity Read ↗

Identification and characterization of two novel melanocortin-3 receptor mutations in Chinese obese individuals.Semantic proximity Read ↗

Association between MC4R rs17782313 genotype and obesity: A meta-analysis.Semantic proximity Read ↗

Genetic variants in the MC4R gene and risk of obesity/overweight: A systematic review and meta-analysis.Semantic proximity Read ↗

Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.Semantic proximity Read ↗

The Melanocortin 4 Receptor p.Ile269Asn Mutation Is Associated with Childhood and Adult Obesity in Mexicans.Semantic proximity Read ↗

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.Semantic proximity Read ↗

Melanocortin 3 receptor gene and melanocortin 4 receptor gene mutations: the Asian Perspective.Semantic proximity Read ↗

Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor.Semantic proximity Read ↗

Identification of three novel genetic variants in the melanocortin-3 receptor of obese children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.