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Article

Clinical development of demethylating agents in hematology

1 Jan 2014

Abstract excerpt

The term epigenetics refers to the heritable changes in gene expression that are not associated with a change in the actual DNA sequence. Epigenetic dysregulation is linked to the pathogenesis of a number of malignancies and has been studied extensively in myelodysplastic syndromes and acute myeloid leukemia. DNA methylation is frequently altered in cancerous cells and likely results in transcriptional silencing...

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PMID: 24382388
DOI: 10.1172/jci69739

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