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Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents

5 Jul 2023

Abstract excerpt

Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hematologic and solid tumors. Based on the capacity of the compounds to inhibit DNA methyltransferase enzymes and the important role of DNA methylation in health and disease, it is...

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PMID: 37489400
DOI: 10.3390/epigenomes7030012

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