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Demethylating Agents in the Treatment of Cancer

2 Jul 2010

Abstract excerpt

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating agents, azacitidine and decitabine, are approved for the treatment of myelodysplastic syndromes (MDS) by the U.S. Food and Drug Administration (FDA), and are now...

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PMID: 27713340
DOI: 10.3390/ph3072022

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