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Review: Recent Clinical Trials in Epigenetic Therapy

1 May 2006

Abstract excerpt

Epigenetic factors such as DNA methylation and histone deacetylation are known to contribute to the malignant transformation of cells by silencing critical genes. Drugs that inhibit DNA methyltransferases or histone deacetylases were shown to have the potential to reactivate silenced genes and induce differentiation or apoptosis of malignant cells. The most intensively studied class of such agents is DNA...

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PMID: 18473969
DOI: 10.2174/157488706776876490

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