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Article

The use of hypomethylating agents in the treatment of hematologic malignancies

1 Jan 2007

Abstract excerpt

Epigenetic alterations, such as DNA methylation and histone modifications, are abnormal in cancer cells, and the use of the hypomethylating agents 5-azacitidine and decitabine are important additions to our arsenal of active cancer drugs, especially for the treatment of the myelodysplastic syndromes and acute myeloid leukemia. Most effective are repeated cycles of the drugs given at doses much lower than...

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PMID: 17786703
DOI: 10.1080/10428190701493910

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