Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.

Current pharmaceutical design - 1 Jan 2013

Sohma Yoshiro, Yu Ying-Chun, Hwang Tzyh-Chang

Abstract excerpt

Genistein and curcumin are major components of Asian foods, soybean and curry turmeric respectively. These compounds have been intensively investigated for their chemical and biological features conferring their anti-cancer activity. Genistein and curcumin have also been investigated for their potentiation effects on disease-associated CFTR mutants such as ΔF508 and G551D. Recently, we investigated the combined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Curcumin
Share to Drug Discovery
Share to Drug Synergism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genistein

Share to Ion Channel Gating

Share to Membrane Potentials

Share to Molecular Structure

Share to Patch-Clamp Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 23331029
DOI: 10.2174/13816128113199990320
PMCID: PMC4939248

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.PMID 23331029Read ↗

Potentiator synergy in rectal organoids carrying S1251N, G551D, or F508del CFTR mutations.Semantic proximity Read ↗

CFTR pharmacology.Semantic proximity Read ↗

Current development of CFTR potentiators in the last decade.Semantic proximity Read ↗

Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.Semantic proximity Read ↗

Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.Semantic proximity Read ↗

Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol.Semantic proximity Read ↗

A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.Semantic proximity Read ↗

Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.Semantic proximity Read ↗

Nanomolar-potency 'co-potentiator' therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants.Semantic proximity Read ↗

CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR.Semantic proximity Read ↗

A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D MutationSemantic proximity Read ↗

Peptide CIGB-552 has a synergistic effect on CFTR-F508del combined with Elexacaftor/Tezacaftor/IvacaftorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.