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Article

CFTR pharmacology.

Cellular and molecular life sciences : CMLS - 1 Jan 2017

Zegarra-Moran Olga, Galietta Luis J V

Abstract excerpt

CFTR protein is an ion channel regulated by cAMP-dependent phosphorylation and expressed in many types of epithelial cells. CFTR-mediated chloride and bicarbonate secretion play an important role in the respiratory and gastrointestinal systems. Pharmacological modulators of CFTR represent promising drugs for a variety of diseases. In particular, correctors and potentiators may restore the activity of CFTR in...

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Topics

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Share to Bicarbonates
Share to Chlorides
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Drug Discovery

Share to Epithelial Cells

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Source

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Identifiers

PMID: 27704174
DOI: 10.1007/s00018-016-2392-x
PMCID: PMC11107536

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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