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Article

Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions.

Traffic (Copenhagen, Denmark) - 1 Jan 2017

Jiang Yuwei, Di Gregorio Sonja E, Duennwald Martin L, Lajoie Patrick

Abstract excerpt

The palette of fluorescent proteins (FPs) available for live-cell imaging contains proteins that strongly differ in their biophysical properties. FPs cannot be assumed to be equivalent and in certain cases could significantly perturb the behavior of fluorescent reporters. We employed Saccharomyces cerevisiae to comprehensively study the impact of FPs on the toxicity of polyglutamine (polyQ) expansion proteins...

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PMID: 27734565
DOI: 10.1111/tra.12453

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