Article
Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
PloS one - 1 Jan 2013
Li Wen, Okuda Akico, Yamamoto Hideyuki, Yamanishi Kyosuke, Terada Nobuyuki, Yamanishi Hiromichi, Tanaka Yoshimasa, Okamura Haruki
Abstract excerpt
Human γδ T cells augment host defense against tumors and infections, and might have a therapeutic potential in immunotherapy. However, mechanism of γδ T cell proliferation is unclear, and therefore it is difficult to prepare sufficient numbers of γδ T cells for clinical immunotherapy. Recently, natural killer (NK)-like CD56(bright)CD11c(+) cells were shown to promote the proliferation of γδ T cells in an...
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