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Article

EMILIN2 down-modulates the Wnt signalling pathway and suppresses breast cancer cell growth and migration.

The Journal of pathology - 1 Mar 2014

Marastoni Stefano, Andreuzzi Eva, Paulitti Alice, Colladel Roberta, Pellicani Rosanna, Todaro Federico, Schiavinato Alvise, Bonaldo Paolo, Colombatti Alfonso, Mongiat Maurizio

Abstract excerpt

EMILIN2 is an extracellular matrix (ECM) protein that exerts contradictory effects within the tumour microenvironment: it induces apoptosis in a number of tumour cells, but it also enhances tumour neo-angiogenesis. In this study, we describe a new mechanism by which EMILIN2 attenuates tumour cell viability. Based on sequence homology with the cysteine-rich domain (CRD) of the Frizzled receptors, we hypothesized...

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Source

Identifiers

PMID: 24374807
DOI: 10.1002/path.4316

Genes

EMILIN2
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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