Article

WNT11 is a novel ligand for ROR2 in human breast cancer

2020-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer has been associated with activation of the WNT signaling pathway, although the underlying molecular mechanisms are still unclear. Here, we found the WNT receptor ROR2 to be highly expressed in aggressive breast tumors and associated with worse metastasis-free survival. In order to understand the molecular basis of these observations, we overexpressed ROR2 in human breast cancer cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ddd62b7-38bf-5a76-bda5-bb1f7316b7e4
DOI: 10.1101/2020.12.18.423402

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WNT11 is a novel ligand for ROR2 in human breast cancerDOI 10.1101/2020.12.18.423402Read

Ror2 Signaling and Its Relevance in Breast Cancer ProgressionSemantic proximity Read

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasionSemantic proximity Read

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic InterventionSemantic proximity Read

ROR2 promotes the epithelial-mesenchymal transition by regulating MAPK/p38 signaling pathway in breast cancer.Semantic proximity Read

Migration and invasion is inhibited by silencing ROR1 and ROR2 in chemoresistant ovarian cancerSemantic proximity Read

Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma.Semantic proximity Read

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.Semantic proximity Read

ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneitySemantic proximity Read

Characterization of a P-Rex1 gene signature in breast cancer cellsSemantic proximity Read

An update of Wnt signalling in endometrial cancer and its potential as a therapeutic targetSemantic proximity Read

Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic diseaseSemantic proximity Read

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.Semantic proximity Read