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Article

Regulation of MT1-MMP Activity through Its Association with ERMs.

Cells - 3 Feb 2020

Suárez Henar, López-Martín Soraya, Toribio Victor, Zamai Moreno, Hernández-Riquer María Victoria, Genís Laura, Arroyo Alicia García, Yáñez-Mó María

Abstract excerpt

Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on...

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Identifiers

PMID: 32028690
DOI: 10.3390/cells9020348
PMCID: PMC7072721

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