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Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

4 Sept 2017

Abstract excerpt

Wnt/β-catenin signaling is instrumental for the development of mammary gland and the properties of mammary stem cells (MaSCs). The Wnt signaling downstream effectors that engage in regulating MaSCs have not been extensively studied. Here, we report that Neuropilin-1 (Nrp1) expression is induced by Wnt/β-catenin signaling in MaSCs, and its function is critical for the activity of MaSCs. Nrp1 is particularly...

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PMID: 28887477
DOI: 10.1038/s41598-017-11287-w

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