Article
Identifying recombination hot spots in the HIV-1 genome.
Journal of virology - 1 Mar 2014
Smyth Redmond P, Schlub Timothy E, Grimm Andrew J, Waugh Caryll, Ellenberg Paula, Chopra Abha, Mallal Simon, Cromer Deborah, Mak Johnson, Davenport Miles P
Abstract excerpt
UNLABELLED: HIV-1 infection is characterized by the rapid generation of genetic diversity that facilitates viral escape from immune selection and antiretroviral therapy. Despite recombination's crucial role in viral diversity and evolution, little is known about the genomic factors that influence recombination between highly similar genomes. In this study, we use a minimally modified full-length HIV-1 genome and...
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