Article
Mechanisms and factors that influence high frequency retroviral recombination.
Viruses - 1 Sept 2011
Delviks-Frankenberry Krista, Galli Andrea, Nikolaitchik Olga, Mens Helene, Pathak Vinay K, Hu Wei-Shau
Abstract excerpt
With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with...
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