Article

A Model of Non-Homologous Recombination Mediated by HIV-1 Reverse Transcriptase Explaining Sequence Motif Duplications That Confer a Replication Fitness Advantage

2025-03-25

Abstract excerpt

The Reverse Transcriptase of the Human Immunodeficiency Virus (HIV) is distinguished for its high rate of homologous recombination. A less-studied consequence of this phenomenon is the increased occurrence of non-homologous recombination, which results in length polymorphism. While most of these genome-wide variations are sporadic, some provide a replication advantage to variant strains, such as those in the Long...

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Literature Corpus work: 426878b8-726e-5087-8a33-e487a468cfb8
DOI: 10.20944/preprints202503.1746.v1

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