Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.

doi:10.1038/s41467-018-04217-5

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Article

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.

Nature communications - 15 May 2018

Song Hongshuo, Giorgi Elena E, Ganusov Vitaly V, Cai Fangping, Athreya Gayathri, Yoon Hyejin, Carja Oana, Hora Bhavna, Hraber Peter, Romero-Severson Ethan, Jiang Chunlai, Li Xiaojun, Wang Shuyi, Li Hui, Salazar-Gonzalez Jesus F, Salazar Maria G, Goonetilleke Nilu, Keele Brandon F, Montefiori David C, Cohen Myron S, Shaw George M, Hahn Beatrice H, McMichael Andrew J, Haynes Barton F, Korber Bette, Bhattacharya Tanmoy, Gao Feng

Abstract excerpt

Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of within-host diversification is less understood. Here we develop a novel computational tool (RAPR (Recombination Analysis PRogram)) to enable a detailed view of in vivo viral recombination during early infection, and we apply it to near-full-length HIV-1 genome sequences from longitudinal samples. Recombinant genomes...

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PMID: 29765018
DOI: 10.1038/s41467-018-04217-5
PMCID: PMC5954121

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