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The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination

31 Aug 2009

Abstract excerpt

The genetic diversity of human immunodeficiency virus type 1 (HIV-1) results from a combination of point mutations and genetic recombination, and rates of both processes are unusually high. This review focuses on the mechanisms and outcomes of HIV-1 genetic recombination and on the parameters that make recombination so remarkably frequent. Experimental work has demonstrated that the process that leads to...

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PMID: 19721086
DOI: 10.1128/mmbr.00012-09

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