Article
Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.
Journal of virology - 1 Aug 2010
Galli Andrea, Kearney Mary, Nikolaitchik Olga A, Yu Sloane, Chin Mario P S, Maldarelli Frank, Coffin John M, Pathak Vinay K, Hu Wei-Shau
Abstract excerpt
High-frequency recombination is a hallmark of HIV-1 replication. Recombination can occur between two members of the same subtype or between viruses from two different subtypes, generating intra- or intersubtype recombinants, respectively. Many intersubtype recombinants have been shown to circulate in human populations. We hypothesize that sequence diversity affects the emergence of viable recombinants by...
Topics
- Cell Line
- Cluster Analysis
- Evolution, Molecular
- Genotype
- HIV-1
- Humans
- Phylogeny
- RNA, Viral
- Recombination, Genetic
- Selection, Genetic