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Article

Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants.

PloS one - 1 Jan 2013

Chen Xufeng, Radany Eric H, Wong Patty, Ma Shenglin, Wu Kan, Wang Bing, Wong Jeffrey Y C

Abstract excerpt

Histone deacetylase inhibitors (HDIs) have shown promise as candidate radiosensitizer for many types of cancers. However, the mechanisms of action are not well understood, and whether they could have clinical impact on radiotherapy for leukemia is unclear. In this study, we demonstrate that suberoylanilide hydroxamic acid (SAHA) can increase radiosensitivity of acute myeloid leukemia (AML) cells through...

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Source

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Identifiers

PMID: 24367670
DOI: 10.1371/journal.pone.0084515
PMCID: PMC3868602

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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