Article
Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination.
Journal of radiation research - 1 Jul 2014
Ohara Maki, Funyu Yumi, Ebara Shunsuke, Sakamoto Yuki, Seki Ryota, Iijima Kenta, Ohishi Akiko, Kobayashi Junya, Komatsu Kenshi, Tachibana Akira, Tauchi Hiroshi
Abstract excerpt
Ionizing radiation induces DNA double-strand breaks (DSBs). Mammalian cells repair DSBs through multiple pathways, and the repair pathway that is utilized may affect cellular radiation sensitivity. In this study, we examined effects on cellular radiosensitivity resulting from functional alteratio...
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