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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

17 Mar 1998

Abstract excerpt

Hybrid polar compounds (HPCs) have been synthesized that induce terminal differentiation and/or apoptosis in various transformed cells. We have previously reported on the development of the second-generation HPCs suberoylanilide hydroxamic acid (SAHA) and m-carboxycinnamic acid bishydroxamide (CBHA) that are 2,000-fold more potent inducers on a molar basis than the prototype HPC hexamethylene bisacetamide (HMBA)....

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PMID: 9501205
DOI: 10.1073/pnas.95.6.3003

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