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Article

Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2011

Seo Sung-Keum, Jin Hyeon-Ok, Woo Sang-Hyeok, Kim Young-Sun, An Sungkwan, Lee Jae-Ho, Hong Seok-Il, Lee Kee-Ho, Choe Tae-Boo, Park In-Chul

Abstract excerpt

INTRODUCTION: Histone deacetylase inhibitors (HDACIs) induce growth arrest and apoptosis in cancer cells. In addition to their intrinsic anticancer properties, HDACIs modulate cellular responses to ionizing radiation (IR). We examined the molecular mechanism(s) associated with the radiosensitizing effects of HDACIs in human lung cancer cells. METHODS: Lung cancer cells were pretreated with the appropriate...

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Identifiers

PMID: 21642861
DOI: 10.1097/JTO.0b013e318220caff

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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