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Article

Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway.

The Journal of biological chemistry - 26 Mar 2010

Rosato Roberto R, Kolla Sarah S, Hock Stefanie K, Almenara Jorge A, Patel Ankita, Amin Sanjay, Atadja Peter, Fisher Paul B, Dent Paul, Grant Steven

Abstract excerpt

Mechanisms underlying histone deacetylase inhibitor (HDACI)-mediated NF-kappaB activation were investigated in human leukemia cells. Exposure of U937 and other leukemia cells to LBH-589 induced reactive oxygen species (ROS) followed by single strand (XRCC1) and double strand (gamma-H2AX) DNA breaks. Notably, LBH-589 lethality was markedly attenuated by small interfering RNA (siRNA) knockdown of the DNA...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20065354
DOI: 10.1074/jbc.M109.095208
PMCID: PMC2843169

Genes

ATM
LBH
SOD2
TRAF2
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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