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Article

Optical control of trimeric P2X receptors and acid-sensing ion channels.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Browne Liam E, Nunes João P M, Sim Joan A, Chudasama Vijay, Bragg Laricia, Caddick Stephen, North R Alan

Abstract excerpt

P2X receptors are trimeric membrane proteins that function as ion channels gated by extracellular ATP. We have engineered a P2X2 receptor that opens within milliseconds by irradiation at 440 nm, and rapidly closes at 360 nm. This requires bridging receptor subunits via covalent attachment of 4,4'-bis(maleimido)azobenzene to a cysteine residue (P329C) introduced into each second transmembrane domain. The cis-trans...

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Identifiers

PMID: 24367083
DOI: 10.1073/pnas.1318582111
PMCID: PMC3890850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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