Article
An additional substrate binding site in a bacterial phenylalanine hydroxylase.
European biophysics journal : EBJ - 1 Sept 2013
Ronau Judith A, Paul Lake N, Fuchs Julian E, Corn Isaac R, Wagner Kyle T, Liedl Klaus R, Abu-Omar Mahdi M, Das Chittaranjan
Abstract excerpt
Phenylalanine hydroxylase (PAH) is a non-heme iron enzyme that catalyzes oxidation of phenylalanine to tyrosine, a reaction that must be kept under tight regulatory control. Mammalian PAH has a regulatory domain in which binding of the substrate leads to allosteric activation of the enzyme. However, the existence of PAH regulation in evolutionarily distant organisms, for example some bacteria in which it occurs,...
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