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Article

Bacterial conversion of folinic acid is required for antifolate resistance.

The Journal of biological chemistry - 29 Apr 2011

Ogwang Sam, Nguyen Hoa T, Sherman Marissa, Bajaksouzian Saralee, Jacobs Michael R, Boom W Henry, Zhang Guo-Fang, Nguyen Liem

Abstract excerpt

Antifolates, which are among the first antimicrobial agents invented, inhibit cell growth by creating an intracellular state of folate deficiency. Clinical resistance to antifolates has been mainly attributed to mutations that alter structure or expression of enzymes involved in de novo folate synthesis. We identified a Mycobacterium smegmatis mutant, named FUEL (which stands for folate utilization enzyme for...

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Identifiers

PMID: 21372133
DOI: 10.1074/jbc.M111.231076
PMCID: PMC3083218

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MTHFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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