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Phylogenetic and Structural Significance of Dihydrofolate Synthase (folC) Mutations in Drug-Resistant Mycobacterium tuberculosis.

Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2016

Cheng Vincent Wing-Sang, Leung Kenneth Siu-Sing, Kwok Jamie Sui-Lam, Leung Ross Ka-Kit, Yang Kevin Yi, Chan Raphael Chiu-Yeung, Kam Kai-Man, Tsui Stephen Kwok-Wing

Abstract excerpt

The aim of this study is to investigate the mutation pattern of the folC gene in drug-resistant Mycobacterium tuberculosis (MTB) clinical isolates of global and Hong Kong cohorts. The public sequence read archives of 1,124 MTB genomes from three independent studies were retrieved and folC mutations existing solely in drug-resistant MTB strains were identified. A phylogenetic tree was constructed to analyze the...

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PMID: 27082669
DOI: 10.1089/mdr.2015.0193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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