Article
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Nature chemical biology - 1 Feb 2014
Dominguez Eduardo, Galmozzi Andrea, Chang Jae Won, Hsu Ku-Lung, Pawlak Joanna, Li Weiwei, Godio Cristina, Thomas Jason, Partida David, Niessen Sherry, O'Brien Paul E, Russell Aaron P, Watt Matthew J, Nomura Daniel K, Cravatt Benjamin F, Saez Enrique
Abstract excerpt
Phenotypic screening is making a comeback in drug discovery as the maturation of chemical proteomics methods has facilitated target identification for bioactive small molecules. A limitation of these approaches is that time-consuming genetic methods or other means are often required to determine the biologically relevant target (or targets) from among multiple protein-compound interactions that are typically...
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