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Article

Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis.

Biochimica et biophysica acta. Molecular and cell biology of lipids - 1 Jul 2018

Lian Jihong, Bahitham Wesam, Panigrahi Rashmi, Nelson Randal, Li Lena, Watts Russell, Thiesen Aducio, Lemieux M Joanne, Lehner Richard

Abstract excerpt

Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with increased lipid storage and plasma lipid concentration. Here we investigated structural and metabolic consequences of a single nucleotide polymorphism in CES1 gene that results in p.Gly143Glu amino acid substitution. We generated a humanized mouse model...

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Source

Identifiers

PMID: 29631096
DOI: 10.1016/j.bbalip.2018.04.002

Genes

CES1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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