Article
A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.
EBioMedicine - 1 Jun 2016
Tschapalda Kirsten, Zhang Ya-Qin, Liu Li, Golovnina Kseniya, Schlemper Thomas, Eichmann Thomas O, Lal-Nag Madhu, Sreenivasan Urmila, McLenithan John, Ziegler Slava, Sztalryd Carole, Lass Achim, Auld Douglas, Oliver Brian, Waldmann Herbert, Li Zhuyin, Shen Min, Boxer Matthew B, Beller Mathias
Abstract excerpt
Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications is of great interest. Here we screened >320.000 compounds for their ability to prevent a cellular lipid accumulation phenotype. We used fly cells because the multifarious tools available for this organism should facilitate unraveling the...
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