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Article

CDK7 regulates the mitochondrial localization of a tail-anchored proapoptotic protein, Hid.

Cell reports - 26 Dec 2013

Morishita Jun, Kang Min-Ji, Fidelin Kevin, Ryoo Hyung Don

Abstract excerpt

The mitochondrial outer membrane is a major site of apoptosis regulation across phyla. Human and C. elegans Bcl-2 family proteins and Drosophila Hid require the C-terminal tail-anchored (TA) sequence in order to insert into the mitochondrial membrane, but it remains unclear whether cytosolic proteins actively regulate the mitochondrial localization of these proteins. Here, we report that the cdk7 complex...

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Identifiers

PMID: 24360962
DOI: 10.1016/j.celrep.2013.11.030
PMCID: PMC3892150

Genes

CDK7

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