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Article

DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.

Nature cell biology - 1 Aug 2014

Sendoel Ataman, Maida Simona, Zheng Xue, Teo Youjin, Stergiou Lilli, Rossi Carlo-Alberto, Subasic Deni, Pinto Sergio M, Kinchen Jason M, Shi Moyin, Boettcher Steffen, Meyer Joel N, Manz Markus G, Bano Daniele, Hengartner Michael O

Abstract excerpt

Microtubule-targeting chemotherapeutics induce apoptosis in cancer cells by promoting the phosphorylation and degradation of the anti-apoptotic BCL-2 family member MCL1. The signalling cascade linking microtubule disruption to MCL1 degradation remains however to be defined. Here, we establish an in vivo screening strategy in Caenorhabditis elegans to uncover genes involved in chemotherapy-induced apoptosis. Using...

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Source

Identifiers

PMID: 25064737
DOI: 10.1038/ncb3010

Genes

MCL1
DEPDC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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