Article
The molecular archaeology of a mitochondrial death effector: AIF in Drosophila.
Cell death and differentiation - 1 Jun 2008
Joza N, Galindo K, Pospisilik J A, Benit P, Rangachari M, Kanitz E E, Nakashima Y, Neely G G, Rustin P, Abrams J M, Kroemer G, Penninger J M
Abstract excerpt
Apoptosis-inducing factor (AIF) is a phylogenetically conserved redox-active flavoprotein that contributes to cell death and oxidative phosphorylation in Saccharomyces cerevisiae, Caenorhabditis elegans, mouse and humans. AIF has been characterized as a caspase-independent death effector that is activated by its translocation from mitochondria to the cytosol and nucleus. Here, we report the molecular...
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