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Article

Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C. elegans.

Development (Cambridge, England) - 1 Sept 2006

Han Sung Min, Lee Tae Hoon, Mun Ji Young, Kim Moon Jeong, Kritikou Ekaterini A, Lee Se-Jin, Han Sung Sik, Hengartner Michael O, Koo Hyeon-Sook

Abstract excerpt

DICE1 (deleted in cancer 1), first identified in human lung carcinoma cell lines, is a candidate tumor suppressor, but the details of its activity remain largely unknown. We have found that RNA interference of its C. elegans homolog (DIC-1) produced inviable embryos with increased apoptosis, cavities in cells and abnormal morphogenesis. In the dic-1(RNAi) germ line, ced-3-dependent apoptosis increased, and cell...

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PMID: 16914495
DOI: 10.1242/dev.02534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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