Article
Integrated amplification microarray system in a lateral flow cell for warfarin genotyping from saliva.
Clinica chimica acta; international journal of clinical chemistry - 15 Feb 2014
Sebastian Thomas, Cooney Christopher G, Parker Jennifer, Qu Peter, Perov Alexander, Golova Julia B, Pozza Lindsay, Iwasiow Rafal M, Holmberg Rebecca
Abstract excerpt
BACKGROUND: Genetic polymorphisms in the CYP2C9 and VKORC1 genes have been linked to sensitivity of the anticoagulant drug warfarin. The aim of this study is to demonstrate a method for warfarin sensitivity genotyping using gel element microarray technology in a simplified workflow from sample collection to analysis and detection. METHODS: We developed an integrated amplification microarray system combining PCR...
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